The DNA binding property of PML/RARA but not the integrity of PML nuclear bodies is indispensable for leukemic transformation.

PML/RARA is the oncoprotein driving acute promyelocytic leukemia (APL).It suppresses genes expression by recruitment of a number of transcriptional repressors, resulting in Dental Floss differentiation block and malignant transformation of hematopoietic cells.Here, we found that mice primary hematopoietic progenitor cells (HPCs), transduced by DNA-

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The Impact of E-Cigarettes on Oral Injuries and Bone Fractures

Introduction The rising prevalence of electronic cigarette (e-cigarette) use has prompted concerns regarding its potential health implications.While much attention has focused on respiratory and cardiovascular NITRO TECH effects, injuries, oral trauma, and bone fractures linked to e-cigarette use have received less scrutiny.This paper aims to compr

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